Planting the seeds for a forest of RNAi pathways

Planting the seeds for a forest of RNAi pathways

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Cells from most eukaryotic species make several different types of small interfering RNAs.Pioneering work in plants, published in PLOS Biology almost 20 years ago, velgen vff 12 established a framework to understand how multiple RNA interference pathways can regulate the genome in parallel.This Perspective looks back at a classic PLOS Biology paper that provided an early glimpse of the complexity of RNAi pathways the flash batman poster in plants and how it acted as a springboard for further exploration of this extravagant universe.